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【公司名稱】 廣州健侖生物科技有限公司
【市場部】 楊永漢
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【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室
在保羅-李博士看來,“胰島素敏感性提升與棕色脂肪的增加同步,在未來,這或許能開啟新的治療方法,阻礙糖分代謝。另一方面,由于當代社會供熱上升,人們在輕度寒冷的條件下暴露的時間減短,這可能損害棕色脂肪的功能,造成肥胖、代謝紊亂。”
“研究顯示,過去幾十年中在英國、美國家庭臥室、餐廳、客廳的溫度從19攝氏度攀升至22攝氏度,這也將導(dǎo)致棕色脂肪生成減弱。因此,除了不健康的飲食、缺乏運動之外,在較高溫度下暴露時間增長,也可能是導(dǎo)致肥胖的因素之一。”
蠑螈成功再生身體部位的秘密正在被揭開,倫敦大學(xué)學(xué)院的研究人員為了將其應(yīng)用于人類。首先,研究人員發(fā)現(xiàn)‘ERK通路’必須不斷地活動為蠑螈細胞進行重新編程,從而能夠有助于不同身體部位的再生。
該研究小組發(fā)現(xiàn)在蠑螈和哺乳動物之間這一通路的主要差異,有助于我們理解為什么人類不能再生四肢,并揭示人類細胞的再生怎樣改善。文章發(fā)表在《Stem Cell Reports 》期刊上。
研究證明ERK通路在哺乳動物細胞中并不十分活躍,但是當強迫其不斷活動時,使得細胞更多可能性為重編程和再生。這可能有助于研究人員更好了解疾病并設(shè)計新療法。
這項研究的*研究員,Max Yun 博士(倫敦大學(xué)學(xué)院結(jié)構(gòu)與分子生物學(xué))說:“雖然人類只有有限的再生能力,其他生物,如蠑螈,能夠再生復(fù)雜結(jié)構(gòu)的所有組成成分,包括它們的心臟、眼睛、脊髓、尾巴等部分,而且它們是*的成體脊椎動物能夠再生出完整四肢的。”
In Dr. Paul Lee's view, "Insulin sensitivity increases in tandem with the increase in brown fat, which in the future may open new avenues of treatment that will hinder sugar metabolism." On the other hand, people are being light due to rising heat in today's society Degrees of exposure to cold conditions are reduced, which may impair the function of brown fat, causing obesity and metabolic disorders. "
Studies have shown that in the United Kingdom in the past decades, the temperature in American family bedrooms, dining rooms and living rooms has risen from 19 degrees Celsius to 22 degrees Celsius, which will also lead to a decrease in brown fat production, so in addition to an unhealthy diet and lack of exercise, Exposure to increased temperatures at higher temperatures may also be one of the factors contributing to obesity. "
The secrets of successfully regenerating the body parts of the salamander are being uncovered, and researchers at the University College London apply it to humans. First, the researchers found that the 'ERK pathway' must be constantly reprogrammed for salamander cells to help regenerate different parts of the body.
The team found that the major differences in this pathway between salamander and mammals helped us to understand why humans can not regenerate their limbs and reveal how human cell regeneration can improve. Article published in "Stem Cell Reports" journal.
Studies have shown that the ERK pathway is not very active in mammalian cells, but when forced to continue its activity, the cells are more likely to be reprogrammed and regenerated. This may help researchers better understand the disease and design new therapies.
Dr. Max Yun, chief researcher of the study, Structural and Molecular Biology, University College London, said: "While humans have only limited ability to regenerate, other organisms, such as salamanders, are able to regenerate all the components of a complex structure, including their Heart, eyes, spinal cord, tail and other parts, and they are the only adult vertebrates capable of regenerating intact limbs. "